Cyclobenzaprine with ibuprofen versus ibuprofen alone in acute myofascial strain: A randomized, double-blind clinical trial

However, in general, physicians will prescribe Flexeril dosages according to the guidelines below as provided by the Mayo Clinic. Any muscle relaxant, including the following list, should be effective in treating acute muscle pain/spasms when used at the proper dose. Although Skelaxin and Flexeril are both in the same drug category (skeletal muscle relaxants), they do have some differences, such as side effects, dose, and pricing, as outlined above.

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Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. You’ll also want to avoid alcohol if you’re taking muscle relaxers, according to theCleveland Clinic. Combining these two can cause extreme dizziness or drowsiness, low blood pressure, or liver damage. Muscle relaxants affect your nervous system, so taking another drug that affects your nervous system such as opioids or psychotropics should be avoided, according to Healthline.

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You may report side effects to FDA at FDA-1088 or at /medwatch. Drowsiness, dizziness, dry mouth, constipation, robaxin 750 vs flexeril or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

These two medications- Flexeril and Ibuprofen, don’t show any interactions. Flexeril and ibuprofen can provide a more comprehensive approach to managing back pain when used together. Flexeril helps to relax the muscles and relieve muscle spasms, while ibuprofen targets the inflammation contributing to the pain. This combination can be particularly effective for individuals who experience muscle-related pain and back inflammation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

• In this section, information about some of these benzodiazepines that may interact with these drugs will be discussed.
• Interventions  All participants were given 20 tablets of naproxen, 500 mg, to be taken twice a day.
• And when this dependency gets out of hand, Flexeril addiction is possible, which can have long-term implications and health effects that can end up tearing apart your life as you know it.
• Having said this, muscle relaxants are potent inhibitors of CYP3A4 that can increase the plasma concentrations of Xanax.

Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs for low back pain. Systematic reviews and meta-analyses support using skeletal muscle relaxants for short-term relief of acute low back pain when nonsteroidal anti-inflammatory drugs or acetaminophen are not effective or tolerated. Comparison studies have not shown one skeletal muscle relaxant to be superior to another.

What do I Need to Know About Taking Flexeril?

Flexeril and Diazepam are both used to treat muscle spasms. They belong to two different drug classes – muscle relaxant and benzodiazepine, respectively. The only salient difference is that Valium has a higher potential to cause drug dependency than Flexeril. However, your physician can better decide which drug is better for your back pain. The drug Cyclobenzaprine, sold under the brand Flexeril, is structurally very similar to a class of Antidepressants called Tricyclic Antidepressants. Flexeril is commonly prescribed to induce pain relief from muscle spasms and improve motor skills, sleep, and energy levels by generating pain relief.

So, please don’t discount the need for professional treatment if you’re addicted to Flexeril. If you attempt to quit using it on your own, you put yourself at risk for an overdose. This is often why people will be admitted into an addiction treatment clinic for Flexeril withdrawal. During cyclobenzaprine addiction treatment, the medication will be slowly tapered off by a reduction of amounts over a certain time frame. This can help patients avoid the discomfort of withdrawing from cyclobenzaprine. The Skelaxin manufacturer information states, “Post-marketing experience has not revealed evidence of fetal injury, but such experience cannot exclude the possibility of infrequent or subtle damage to the human fetus.

Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911. The pharmacist performed a stratified randomization in blocks of 6 based on 2 sequences using a randomization plan generator.16 Patients were stratified based on results of the baseline RMDQ. The pharmacist masked the medication by placing cyclobenzaprine, oxycodone/acetaminophen, or placebo into identical unmarked capsules, which were then packed with small amounts of lactose and sealed. The pharmacist created research packets, each with 2 vials of medication, one containing naproxen and the other containing the masked investigational medication. Research packets were dispensed to study participants by research personnel.

Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. However, this does not necessarily mean no interactions exist. With either drug, an allergic reaction is rare but possible. Serotonin syndrome, a life-threatening condition due to serotonin buildup, is also possible. The most common side effects of Flexeril are drowsiness, dizziness, headache, and dry mouth. While the addictiveness of cyclobenzaprine is being debated, anyone exhibiting problematic patterns of substance use can benefit from addiction treatment.

For instance, a person may be seen as using cocaine when they’re not. There are over 12,000 people in the U.S who will go to the emergency room looking to be treated for Flexeril overdose. A study showed that 209 people who overdosed on Flexeril on its own survived the ordeal. Mixing the drug with other substances, however, has shown to cause accidents leading to death. Although both medications are muscle relaxants, they are not exactly the same. Continue reading below to learn more about Skelaxin and Flexeril.